Though PPIs are the mainstay treatment for GERD, up to 30% of patients are PPI-refractory who remain symptomatic despite PPI usage. Most of these refractory patients experience break-through symptoms, including heartburn and regurgitation, at night. Lifestyle changes are often overlooked as a viable treatment for nocturnal GERD symptoms. The only two proven lifestyle changes shown to be effective are weight loss and sleep positioning. By combining incline and left-side sleep positioning, the MedCline Reflux Relief System offers clinically superior results offering relief to the many patients without another treatment alternative.